While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Former Buffalo Bills quarterback Ryan Fitzpatrick recently sang the praises of current field general Josh Allen.

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

Quarterback Tua Tagovailoa has been on a tear since he returned from injured reserve, and his performance in the Miami ...

John Madden’s love of football and family came through the most on Thanksgiving. On Thursday, NBC will continue to honor ...

Like her Buffalo Bills man, Hailee Steinfeld has been on fire lately. The 27-year-old actress, singer, influencer, and ...

The Bills and 49ers meet on Sunday Night Football in a game with playoff implications for both teams. Here are three ...

Simpson carried the ball 29 times against the Lions and set a new NFL record with 273 rushing yards, breaking his own record ...

The Buffalo Bills are heading out of the their bye and are set to face the San Francisco 49ers in Week 13 on “Sunday Night ...

Josh Allen and the Buffalo Bills are coming off their bye week with a 9-2 record and a four game lead in the division.

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...