San Francisco 49ers quarterback Brock Purdy was limited with the right shoulder injury that sidelined him last week and there ...

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...

The 49ers have revealed their latest injury report before their Sunday Night Football tilt against the Buffalo Bills.

Deebo Samuel probably is the most disappointing player on the most disappointing team in the NFL through 12 weeks. Despite ...

Christian McCaffrey has been inefficient in his three games played since dealing with Achilles tendinitis. He doesn't look ...

Head coach Kyle Shanahan explains why the 49ers don't rotate their running backs to give Christian McCaffrey a breather.

One San Francisco 49ers star has been dealing with more pain than was previously known for most of the season.

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an ...

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4.

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out ...