Fantasy managers may need to proceed with caution before placing San Francisco's offensive players in their lineup this week.

Related: Bills Can Make History vs. 49ers on 'SNF' "Lots of things can happen between now and then, but right now he's ...

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff ...

It's Week 13, and the San Francisco 49ers are at 5-6 in the season. The team travels to Buffalo to take on the leaders of the ...

The arrow is pointing upward for Brock Purdy. On Friday, the 49ers delivered encouraging news on Purdy's status vs Buffalo in ...

Los Angeles Chargers (7-4) at Atlanta Falcons (6-5), 1 p.m. ET, FOX Atlanta holds a one-game lead over the Tampa Bay Buccaneers in the NFC South but lost the last ...

But even when most or all of those Niners took the field this year, closing out games has been a glaring weakness for a team expected to compete for the NFC. A loss to Seattle in Week 11 marked the ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

San Francisco 49ers QB Brock Purdy shared his journey through injury recovery and looked ahead to the team's Week 13 matchup ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

LB Fred Warner, WR Deebo Samuel Sr., RB Christian McCaffrey and DL Nick Bosa identified key areas for improvement as the team ...

The 49ers have revealed their latest injury report from Wednesday’s practice before their Sunday Night Football tilt against ...